How fast does vitamin k reverse inr

Although there was no difference in the mean decrease in INR from baseline at 24 hours between the 2 groups, there was a statistically significant difference between the groups at 8 hours, with the IV group achieving a greater correction of INR. Furthermore, there was a significant difference in the mean INR between the 2 groups both at 8 hours 4.

While it is important to correct excessive prolongation of the INR, in patients who are not bleeding, this should be done without putting the patient at risk of treatment-related complications and without causing resistance to subsequent anticoagulation.

Low doses of IV phytonadione 0. Although it is difficult to estimate the frequency of such reactions from a review of the literature, even a small risk of such reactions is unacceptable in a patient who is asymptomatic. The anaphylactic reaction is thought to be related to the presence of polyoxyethylated castor oil in the phytonadione preparation.

Perhaps because of this, the Konakion brand of phytonadione was not approved for IV injections and is no longer available in this country. Aquamephyton brand of phytonadione comes with a product insert warning that IV administration can be associated with serious reactions and should be reserved for emergency situations only. Three studies have evaluated the effectiveness of small oral doses Pengo et al 15 treated 11 patients with a mean INR of 5. All 11 patients had an INR of less than 5 after 24 hours.

In a retrospective study of 58 patients with an INR greater than 5, phytonadione in a dose of 2. The INR decreased to a mean of 2. Our study shows that, although SC administration of 1 mg of phytonadione is effective in correcting excessive anticoagulation from warfarin therapy, the effect is neither as quick nor as complete as after IV administration. If the goal of therapy is to bring the INR rapidly to 5 or less, then SC administration of very small doses of phytonadione may not be very effective, since even at 24 hours, 4 of 11 patients in the SC group in our study had an INR greater than 5.

In conclusion, in patients who have excessive anticoagulation with warfarin, SC administration of very small doses of phytonadione may not correct the INR as rapidly and as effectively as IV administration. However, IV phytonadione may be associated with rare but serious anaphylactic reactions. Further studies are needed to evaluate the efficacy of slightly higher doses of phytonadione administered SC.

Since this study was initiated, the Consensus Conference on Antithrombotic Therapy has revised its guidelines and recommends treating patients who have high INR without bleeding with oral phytonadione: 1 to 2. The authors are indebted to Donald D. Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue.

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Access to free article PDF downloads. Coumadin is the common brand name for warfarin. To ensure that warfarin is effectively thinning your blood, it's important to eat about the same amount of vitamin K every day.

So warfarin and vitamin K work against each other in your body. That is why, when you take warfarin, it's important that you not suddenly eat a lot more or a lot less vitamin K-rich food than you usually do. It's up to you how much vitamin K you choose to eat. For example, if you already eat a lot of leafy green vegetables, that's fine.

Just keep it about the same amount each day. Check with your doctor before you make big changes in what you eat, such as starting a diet to lose weight.

If you want to start eating more of a food that's rich in vitamin K, talk to your doctor about how to add it safely. Your warfarin dose may need to be adjusted. Green and black tea leaves do contain vitamin K before they are steeped in water, but a small serving of the hot tea itself does not. Check with your doctor before you take any supplements or herbal products.

Some of these may contain vitamin K. If you already take a product that contains vitamin K, do not stop taking it without talking with your doctor first.

To find out how well warfarin is working, you will get blood tests to measure how long it takes for your blood to clot. You may just hear about your INR. Your INR needs to be in a safe range—not too high and not too low. Vitamin K can change how warfarin works, which changes your INR. Author: Healthwise Staff. Medical Review: E. This information does not replace the advice of a doctor.

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